Interactions of Polyphenols with the P450 System: Possible Implications on Human Therapeutics

Title: Interactions of Polyphenols with the P450 System: Possible Implications on Human Therapeutics

Volume: 8 Issue: 2

Author(s): M. J. Gomez-Lechon, I. Rodeiro, M. T. Donato, A. Lahoz, G. Garrido and R. Delgado

Affiliation:

Keywords: Antioxidants, flavonoids, polyphenols, cytochrome P450, herbal medicines

Abstract: Polyphenols are a family of natural compounds with many biological properties. This review focuses on their potential interaction on the cytochrome P450 system. Effects of phenolic acids, anthocyanins, stilbenes, catechins and other flavonoids on the drug metabolising function are revised. Their daily intake and presence in herbal medicines justify the study of potential drug-interaction to prevent undesirable clinical consequences.

Cite this article as:

Gomez-Lechon J. M., Rodeiro I., Donato T. M., Lahoz A., Garrido G. and Delgado R., Interactions of Polyphenols with the P450 System: Possible Implications on Human Therapeutics, Mini-Reviews in Medicinal Chemistry 2008; 8 (2) . https://dx.doi.org/10.2174/138955708783498131