Redox State of Cytochrome c Regulates Cellular ROS and Caspase Cascade in Permeablized Cell Model

Jian-Xing      Xu; Min      Li; Ao-Jin      Wang

doi:10.2174/092986608783489490

Abstract

In a permeablized cell system, oxidized cyt c is able to induce caspase cascade whereas reduced cyt c cannot. In in vitro experiments, oxidized cyt c can promote H2O2 generation. It is suggested that the redox state of cyt c might regulate the initiation of apoptosis via regulation of cellular ROS level.

Keywords: Redox state, cytochrome c, apoptosis, caspase

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Protein & Peptide Letters

Title: Redox State of Cytochrome c Regulates Cellular ROS and Caspase Cascade in Permeablized Cell Model

Volume: 15 Issue: 2

Author(s): Jian-Xing Xu, Min Li and Ao-Jin Wang

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Keywords: Redox state, cytochrome c, apoptosis, caspase

Abstract: In a permeablized cell system, oxidized cyt c is able to induce caspase cascade whereas reduced cyt c cannot. In in vitro experiments, oxidized cyt c can promote H2O2 generation. It is suggested that the redox state of cyt c might regulate the initiation of apoptosis via regulation of cellular ROS level.

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Xu Jian-Xing, Li Min and Wang Ao-Jin, Redox State of Cytochrome c Regulates Cellular ROS and Caspase Cascade in Permeablized Cell Model, Protein & Peptide Letters 2008; 15 (2) . https://dx.doi.org/10.2174/092986608783489490