Redox State of Cytochrome c Regulates Cellular ROS and Caspase Cascade in Permeablized Cell Model

Title: Redox State of Cytochrome c Regulates Cellular ROS and Caspase Cascade in Permeablized Cell Model

Volume: 15 Issue: 2

Author(s): Jian-Xing Xu, Min Li and Ao-Jin Wang

Affiliation:

Keywords: Redox state, cytochrome c, apoptosis, caspase

Abstract: In a permeablized cell system, oxidized cyt c is able to induce caspase cascade whereas reduced cyt c cannot. In in vitro experiments, oxidized cyt c can promote H2O2 generation. It is suggested that the redox state of cyt c might regulate the initiation of apoptosis via regulation of cellular ROS level.

Cite this article as:

Xu Jian-Xing, Li Min and Wang Ao-Jin, Redox State of Cytochrome c Regulates Cellular ROS and Caspase Cascade in Permeablized Cell Model, Protein & Peptide Letters 2008; 15 (2) . https://dx.doi.org/10.2174/092986608783489490

DOI https://dx.doi.org/10.2174/092986608783489490	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305