Role of Platelet Signaling in Thrombus Stabilization: Potential Therapeutic Implications

Title: Role of Platelet Signaling in Thrombus Stabilization: Potential Therapeutic Implications

Volume: 3 Issue: 1

Author(s): Anne Angelillo-Scherrer, Francois Saller and Marc Schapira

Affiliation:

Keywords: Thrombus stabilization, thrombosis, antiplatelet drugs, platelet signaling, integrin signaling

Abstract: Platelets initiate arrest of bleeding at sites of vascular injury but also trigger inopportune arterial thrombosis, which causes heart attack and stroke. After formation of a single platelet monolayer at the site of injury, additional platelets are recruited into the growing hemostatic plug. Without further stabilization, the platelet plug disaggregates. Its stabilization is ensured by perpetuation of platelet activation. Drugs designed to prevent thrombus stabilization rather than inhibition of its formation, are currently not available. Platelet signaling of the perpetuation phase of platelet activation might represent a potential target for antiplatelet drugs that would prevent thrombosis without eliciting bleeding.

Cite this article as:

Angelillo-Scherrer Anne, Saller Francois and Schapira Marc, Role of Platelet Signaling in Thrombus Stabilization: Potential Therapeutic Implications, Current Signal Transduction Therapy 2008; 3 (1) . https://dx.doi.org/10.2174/157436208783334268