Essential Factors for Successful Virtual Screening

Markus   H.J.   Seifert; Martin      Lang

doi:10.2174/138955708783331540

Abstract

Virtual high-throughput screening (vHTS) is a powerful technique for identifying hit molecules as starting points for medicinal chemistry. Numerous successful applications of vHTS have been published using a large variety of methodologies. This review attempts to identify the essential factors for successful virtual screening in the hit identification phase.

Keywords: Virtual screening, high-throughput screening, docking, scoring, hit identification, similarity search

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Mini-Reviews in Medicinal Chemistry

Title: Essential Factors for Successful Virtual Screening

Volume: 8 Issue: 1

Author(s): Markus H.J. Seifert and Martin Lang

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Keywords: Virtual screening, high-throughput screening, docking, scoring, hit identification, similarity search

Abstract: Virtual high-throughput screening (vHTS) is a powerful technique for identifying hit molecules as starting points for medicinal chemistry. Numerous successful applications of vHTS have been published using a large variety of methodologies. This review attempts to identify the essential factors for successful virtual screening in the hit identification phase.

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Seifert H.J. Markus and Lang Martin, Essential Factors for Successful Virtual Screening, Mini-Reviews in Medicinal Chemistry 2008; 8 (1) . https://dx.doi.org/10.2174/138955708783331540