Structural and Functional Diversity of Nudix Fold

Title: Structural and Functional Diversity of Nudix Fold

Volume: 15 Issue: 1

Author(s): Yuejin Hua, Jun Lin and Bing Tian

Affiliation:

Keywords: MutT/Nudix superfamily, structural phylogeny, QH, RMSD, cluster analysis, DNA repair

Abstract: Nudix hydrolases catalyze the hydrolysis of nucleoside diphosphates linked to other moieties X, and contain the sequence motif or Nudix box, GX5EX7REUXEEXGU. The mechanisms of Nudix hydrolases are highly diverse in the position on the substrate. In this paper, we examined the sequences and structures of the MutT/Nudix superfamily. And two recent developed methods were employed for data analyses of the superfamily. One is QH method evaluating the similarities among structures for structural phylogeny. The other method is clustering analysis by using the CLANS program that could analysis thousands of sequences of the full dataset rather than the representative sequences of the superfamily. Finally, we proposed a more objective classification of the MutT/Nudix superfamily members based on detailed sequence and structure analyses.

Cite this article as:

Hua Yuejin, Lin Jun and Tian Bing, Structural and Functional Diversity of Nudix Fold, Protein & Peptide Letters 2008; 15 (1) . https://dx.doi.org/10.2174/092986608783330350

DOI https://dx.doi.org/10.2174/092986608783330350	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305