Abstract
A series of bifunctional compounds carrying cluster thiogalactosides L1-L6 as the cell targeting ligands were synthesized for gene delivery to hepatocytes. Tetra-antennary dendr-OMs4 5 was used as a scaffold for the attachment of three galactosides, while the other mesylate end was linked with cholesterol through poly(ethylene glycol) chain with different length. This design provided an effective entry for the synthesis of the bifunctional compound with hepatocytes targeting ability.
Keywords: Cluster, cholesterylated galactosides, targeting ligand, hepatocyte specific delivery, gene delivery
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
2