Abstract
New A-C8 and C-C2-linked 6-chloropurine-pyrrolo[2,1-c][1,4]benzodiazepine hybrids have been prepared and evaluated for their anticancer potential. The molecular modeling studies might be explained in terms of effect of the molecule on binding in the minor groove of DNA and also comparison to both A-C8/C-C2-position of the PBD. These PBD conjugates have shown DNA-binding ability and promising anticancer activity.
Keywords: Pyrrolo[2,1-c][1,4]benzodiazepines, 6-chloropurine nucleosides, DNA-binding affinity, Anticancer activity
Letters in Drug Design & Discovery
Title: Design, Synthesis and Biological Activity of A-C8/C-C2-Linked 6-Chloropurine-Pyrrolobenzodiazepine Hybrids as Anticancer Agents
Volume: 4 Issue: 8
Author(s): Ahmed Kamal, N. Shankaraiah, K. Laxma Reddy, V. Devaiah, Aarti Juvekar and Subrata Sen
Affiliation:
Keywords: Pyrrolo[2,1-c][1,4]benzodiazepines, 6-chloropurine nucleosides, DNA-binding affinity, Anticancer activity
Abstract: New A-C8 and C-C2-linked 6-chloropurine-pyrrolo[2,1-c][1,4]benzodiazepine hybrids have been prepared and evaluated for their anticancer potential. The molecular modeling studies might be explained in terms of effect of the molecule on binding in the minor groove of DNA and also comparison to both A-C8/C-C2-position of the PBD. These PBD conjugates have shown DNA-binding ability and promising anticancer activity.
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Kamal Ahmed, Shankaraiah N., Reddy Laxma K., Devaiah V., Juvekar Aarti and Sen Subrata, Design, Synthesis and Biological Activity of A-C8/C-C2-Linked 6-Chloropurine-Pyrrolobenzodiazepine Hybrids as Anticancer Agents, Letters in Drug Design & Discovery 2007; 4 (8) . https://dx.doi.org/10.2174/157018007782794482
DOI https://dx.doi.org/10.2174/157018007782794482 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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