Recent Progress in the Solid-phase Synthesis of Glycopeptide

Title: Recent Progress in the Solid-phase Synthesis of Glycopeptide

Volume: 1 Issue: 1

Author(s): Hironobu Hojo and Nakahara Nakahara

Affiliation:

Abstract: The recent understanding of the biological role of glycoproteins has brought about a demand for the highly homogeneous glycopeptides as the functional model for glycoproteins. Thus, much efforts have been made to establish easy and efficient method for glycopeptide synthesis. In this paper, we briefly review the recent advances in the synthesis of O- and N-linked glycopeptide based on the solidphase method. In O-glycopeptide section, the preparation of glycosylated amino acid units with mucin type and other O-linked carbohydrate chains and their use for solid-phase synthesis are summarized. Other approaches, such as the glycosylation of resin bound peptide are also overviewed. In Nglycopeptide section, the synthesis using glycosylated amino acid units as well as other methods are described..

Cite this article as:

Hojo Hironobu and Nakahara Nakahara, Recent Progress in the Solid-phase Synthesis of Glycopeptide, Current Protein & Peptide Science 2000; 1 (1) . https://dx.doi.org/10.2174/1389203003381432

DOI https://dx.doi.org/10.2174/1389203003381432	Print ISSN 1389-2037
Publisher Name Bentham Science Publisher	Online ISSN 1875-5550