Syntheses Of Neurotensin (Nt) Analogues And Their Comparative Anorectic Effect On Food Intake In Rats

Title: Syntheses Of Neurotensin (Nt) Analogues And Their Comparative Anorectic Effect On Food Intake In Rats

Volume: 8 Issue: 6

Author(s): T. Abiko and Y. Takamura

Affiliation:

Keywords: NEUROTENSIN (NT) ANALOGUES, anorectic activity, Neurotensin (NT)

Abstract: Five analogues of neurotensin(NT:Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) were prepared by the solid-phase method and their comparative anorectic effects on food intake in rats were examined. Among them, [Phe(NO2)3,11]-NT and [Phe(4F)3,11]-NT showed stronger anorectic activity than that of the parent peptide but [Tyr(Me)3,11]-NT was less active than the parent peptide. On the contrary, the other two analogues, [Sar7,10]-NT and [beta Ala7,10]-NT had no anorectic activity.

Cite this article as:

Abiko T. and Takamura Y., Syntheses Of Neurotensin (Nt) Analogues And Their Comparative Anorectic Effect On Food Intake In Rats, Protein & Peptide Letters 2001; 8 (6) . https://dx.doi.org/10.2174/0929866013409120

DOI https://dx.doi.org/10.2174/0929866013409120	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305