Antibody Directed Enzyme Prodrug Therapy (ADEPT) and Related Approaches for Anticancer Therapy

Title: Antibody Directed Enzyme Prodrug Therapy (ADEPT) and Related Approaches for Anticancer Therapy

Volume: 1 Issue: 4

Author(s): M. Jung

Affiliation:

Keywords: Antibody Directed Enzyme Prodrug Therapy, ADEPT, Anticancer Therapy, Alkaline Phosphatase, Amino Peptidases, Aryl Sulfatase, Carboxylesterase, Carboxypeptidase A, Carboxypeptidase G2 (CpG2), Cytosine Deaminase

Abstract: In antibody directed enzyme prodrug therapy (ADEPT) an antibody bound enzyme is targeted to tumor cells. This allows for selective activation of a nontoxic prodrug to a cytotoxic agent at the tumor site for cancer therapy. Site-selective prodrug activation results in reduced side effects in remote tissue. This article reviews ADEPT with emphasis on the chemical viewpoint and recent developments.

Cite this article as:

Jung M., Antibody Directed Enzyme Prodrug Therapy (ADEPT) and Related Approaches for Anticancer Therapy, Mini-Reviews in Medicinal Chemistry 2001; 1 (4) . https://dx.doi.org/10.2174/1389557013406747