Synthesis and Biological Effects of an Anorectic Peptide Cart (Cocaine- And Amphetamine-Regulated Trascript) (Human55-102) Analogue

Title: Synthesis and Biological Effects of an Anorectic Peptide Cart (Cocaine- And Amphetamine-Regulated Trascript) (Human55-102) Analogue

Volume: 8 Issue: 2

Author(s): T. Abiko and R. Fujimura

Affiliation:

Keywords: Anorectic Peptide

Abstract: [Phe(4F)97]CART55-102 was synthesized by a solid-phase method. Hydrogen fluoride was used to deprotect and cleave the peptide from the resin except for Acm groups and a Met(0) residue. The product was treated with dithiothreitol to remove a sulfoxide group of Met(0) residue and then treated with Hg(OAc)2 in 50percent aqueous AcOH to remove Acm groups. The reduced peptide was subjected to oxidative folding to form disulfide bridges. The crude product was purified by PR-HPLC. The synthetic [Phe(4F)97]CART55-102 and CART55-102 were tested for comparative effect on inhibitory food intake in rats. This peptide exhibited far stronger inhibitory effect than that of the synthetic CART55-102

Cite this article as:

Abiko T. and Fujimura R., Synthesis and Biological Effects of an Anorectic Peptide Cart (Cocaine- And Amphetamine-Regulated Trascript) (Human55-102) Analogue, Protein & Peptide Letters 2001; 8 (2) . https://dx.doi.org/10.2174/0929866013409616

DOI https://dx.doi.org/10.2174/0929866013409616	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305