Triazine Conjugates for Multiple Site-Specific Labeling of Peptides

Jonathan   A.   Zerkowski; Douglas   A.   Schftner

doi:10.2174/0929866013409562

Abstract

Mono- and di-substituted triazines were appended to the side chain of lysine or ornithine, which was then used in the synthesis of peptides. In this way, environment-sensitive reporter groups can be included in a sequence-specific manner in a peptide. The triazine adducts are stable to standard conditions employed in peptide synthesis. Several model peptides showing the utility of these conjugates were prepared

Keywords: triazine, peptides, aminochlorotriszines, fluorophores, ornithine

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Protein & Peptide Letters

Title: Triazine Conjugates for Multiple Site-Specific Labeling of Peptides

Volume: 8 Issue: 2

Author(s): Jonathan A. Zerkowski and Douglas A. Schftner

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Keywords: triazine, peptides, aminochlorotriszines, fluorophores, ornithine

Abstract: Mono- and di-substituted triazines were appended to the side chain of lysine or ornithine, which was then used in the synthesis of peptides. In this way, environment-sensitive reporter groups can be included in a sequence-specific manner in a peptide. The triazine adducts are stable to standard conditions employed in peptide synthesis. Several model peptides showing the utility of these conjugates were prepared

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Zerkowski A. Jonathan and Schftner A. Douglas, Triazine Conjugates for Multiple Site-Specific Labeling of Peptides, Protein & Peptide Letters 2001; 8 (2) . https://dx.doi.org/10.2174/0929866013409562