Medicinal Chemistry of Nicotinamide in the Treatment of Ischemia and Reperfusion

J.      Yang; L.   K.   Klaidman; J.   D.   Adams

doi:10.2174/1389557024605483

Abstract

Nicotinamide can facilitate DNA repair by inhibiting poly(ADP-ribose) polymerase, increasing NAD levels and adjusting other related enzyme activities. This review will summarize recent work on the design of poly(ADP-ribose) polymerase inhibitors, poly(ADP-ribose) glycohydrolase inhibitors and will discuss the possible use of drugs that interact with NAD synthetic enzymes.

Keywords: nicotinamide, poly(adp-ribose) polymerase inhibitors, poly(adp-ribose)glycohydrolase inhibitors, glycohydrolase

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Mini-Reviews in Medicinal Chemistry

Title: Medicinal Chemistry of Nicotinamide in the Treatment of Ischemia and Reperfusion

Volume: 2 Issue: 2

Author(s): J. Yang, L. K. Klaidman and J. D. Adams

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Keywords: nicotinamide, poly(adp-ribose) polymerase inhibitors, poly(adp-ribose)glycohydrolase inhibitors, glycohydrolase

Abstract: Nicotinamide can facilitate DNA repair by inhibiting poly(ADP-ribose) polymerase, increasing NAD levels and adjusting other related enzyme activities. This review will summarize recent work on the design of poly(ADP-ribose) polymerase inhibitors, poly(ADP-ribose) glycohydrolase inhibitors and will discuss the possible use of drugs that interact with NAD synthetic enzymes.

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Yang J., Klaidman K. L. and Adams D. J., Medicinal Chemistry of Nicotinamide in the Treatment of Ischemia and Reperfusion, Mini-Reviews in Medicinal Chemistry 2002; 2 (2) . https://dx.doi.org/10.2174/1389557024605483