Molecular Pharmacophore Determination of Lipid Lowering Drugs with the Receptor Mapping Method

M.      Ablise; A.      Cartier; G.      Siest; S.      Visvikis; V.      Loppinet

doi:10.2174/1389557024605528

Abstract

Hypolipidemic pharmacophoric moieties of statins, fibrates, ACAT inhibitors and beta-sitosterol analog series were identified by computational modeling, and compared with the computed structure of new potential glycyrrhetinic acid derivatives lipid-lowering drugs. Their electronic and geometric domains, similar to those of fibrates, suggest a fibrate -like mechanism matching biochemical data.

Keywords: acat inhibitors, molecular modeling, glycyrrhizin, glycyrrhiza glabra

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Mini-Reviews in Medicinal Chemistry

Title: Molecular Pharmacophore Determination of Lipid Lowering Drugs with the Receptor Mapping Method

Volume: 2 Issue: 2

Author(s): M. Ablise, A. Cartier, G. Siest, S. Visvikis and V. Loppinet

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Keywords: acat inhibitors, molecular modeling, glycyrrhizin, glycyrrhiza glabra

Abstract: Hypolipidemic pharmacophoric moieties of statins, fibrates, ACAT inhibitors and beta-sitosterol analog series were identified by computational modeling, and compared with the computed structure of new potential glycyrrhetinic acid derivatives lipid-lowering drugs. Their electronic and geometric domains, similar to those of fibrates, suggest a fibrate -like mechanism matching biochemical data.

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Ablise M., Cartier A., Siest G., Visvikis S. and Loppinet V., Molecular Pharmacophore Determination of Lipid Lowering Drugs with the Receptor Mapping Method, Mini-Reviews in Medicinal Chemistry 2002; 2 (2) . https://dx.doi.org/10.2174/1389557024605528