The Effect of Fibrillar Aβ1-40 on Membrane Fluidity and Permeability

Title: The Effect of Fibrillar Aβ1-40 on Membrane Fluidity and Permeability

Volume: 9 Issue: 2

Author(s): Xiaocui Ma, Yinlin Sha, Kechun Lin and Songqing Nie

Affiliation:

Keywords: fibrillar, membrane fluidity, ants learage, calcein learage

Abstract: The time course of Aβ fibril formation was characterized using a variety of assays. The effect of Aβ on the membrane fluidity and permeability was assessed by monitoring the anisotropy of the fluorescent probe DPH and TMA-DPH and measuring the release of vesicle-entrapped with three different molecular weight fluorescence probes (ANTS / DPX, Calcein, FD-4). The results show fibrils had formed after 4 days. Aggregated Aβmay decrease the membrane fluidity and induce the leakage of ANTS and Calcein in a dose -dependent manner. These effects may have some relation with Aβ neurotoxicity.

Cite this article as:

Ma Xiaocui, Sha Yinlin, Lin Kechun and Nie Songqing, The Effect of Fibrillar Aβ1-40 on Membrane Fluidity and Permeability, Protein & Peptide Letters 2002; 9 (2) . https://dx.doi.org/10.2174/0929866023408832

DOI https://dx.doi.org/10.2174/0929866023408832	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305