Login Register Cart 0
Generic placeholder image

Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe

The Effect of Fibrillar Aβ1-40 on Membrane Fluidity and Permeability

Author(s): Xiaocui Ma, Yinlin Sha, Kechun Lin and Songqing Nie

Volume 9, Issue 2, 2002

Page: [173 - 178] Pages: 6

DOI: 10.2174/0929866023408832

Price: $65

Abstract

The time course of Aβ fibril formation was characterized using a variety of assays. The effect of Aβ on the membrane fluidity and permeability was assessed by monitoring the anisotropy of the fluorescent probe DPH and TMA-DPH and measuring the release of vesicle-entrapped with three different molecular weight fluorescence probes (ANTS / DPX, Calcein, FD-4). The results show fibrils had formed after 4 days. Aggregated Aβmay decrease the membrane fluidity and induce the leakage of ANTS and Calcein in a dose -dependent manner. These effects may have some relation with Aβ neurotoxicity.

Keywords: fibrillar, membrane fluidity, ants learage, calcein learage

« Previous Next »

Rights & Permissions Print Cite
Article Metrics
3
© 2025 Bentham Science Publishers | Privacy Policy