Abstract
Chemoprotection has established itself as a “major arm” in the “war against cancer” and induction of phase 2 detoxification enzymes as an effective strategy. Prominent among inducers are Michael reaction acceptors. Such functionalities are intrinsic to many phenylpropanoids present in edible plants, where they play roles in plant defense. This minireview focuses on the ability of such plant metabolites to elevate phase 2 enzymes in various cell culture and animal models and ultimately to protect against carcinogenesis.
Keywords: plant phenylpropenoids, mammalian anticarcinogenic enzymes, chemoprotection, edible plants, carcinogenesis, double michael reaction acceptor
Mini-Reviews in Medicinal Chemistry
Title: Protection Against Cancer by Plant Phenylpropenoids: Induction of Mammalian Anticarcinogenic Enzymes
Volume: 2 Issue: 6
Author(s): A. T. Dinkova-Kostova
Affiliation:
Keywords: plant phenylpropenoids, mammalian anticarcinogenic enzymes, chemoprotection, edible plants, carcinogenesis, double michael reaction acceptor
Abstract: Chemoprotection has established itself as a “major arm” in the “war against cancer” and induction of phase 2 detoxification enzymes as an effective strategy. Prominent among inducers are Michael reaction acceptors. Such functionalities are intrinsic to many phenylpropanoids present in edible plants, where they play roles in plant defense. This minireview focuses on the ability of such plant metabolites to elevate phase 2 enzymes in various cell culture and animal models and ultimately to protect against carcinogenesis.
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Cite this article as:
Dinkova-Kostova T. A., Protection Against Cancer by Plant Phenylpropenoids: Induction of Mammalian Anticarcinogenic Enzymes, Mini-Reviews in Medicinal Chemistry 2002; 2 (6) . https://dx.doi.org/10.2174/1389557023405558
DOI https://dx.doi.org/10.2174/1389557023405558 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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