Rational Design of Reversible Acetylcholinesterase Inhibitors

Title: Rational Design of Reversible Acetylcholinesterase Inhibitors

Volume: 2 Issue: 1

Author(s): Xavier Barril, Susana G. Kalko, Modesto Orozco and F. Javier Luque

Affiliation:

Keywords: Acetylcholinesterase Inhibitors, Torpedo californica, Tacrine, Velnacrine, Amiridine, Huperzine, ciclohexenol ring, N-Benzylpiperidines, Torpedo californica AChE

Abstract: A large amount of structural information on AChE and AChE-inhibitor complexes is currently available. Based on that, molecular modeling studies can be intensively used to gain insight into the mechanism of action of the enzyme and the molecular determinants that modulate the potency of inhibitors. In turn, this knowledge can be exploited to design new compounds leading to more effective cholinergic strategies. This manuscript reviews recent developments in the design of reversible acetylcholinesterase inhibitors.

Cite this article as:

Barril Xavier, Kalko G. Susana, Orozco Modesto and Luque Javier F., Rational Design of Reversible Acetylcholinesterase Inhibitors, Mini-Reviews in Medicinal Chemistry 2002; 2 (1) . https://dx.doi.org/10.2174/1389557023406494