Perspectives in Drug Design Against Malaria

Title: Perspectives in Drug Design Against Malaria

Volume: 2 Issue: 5

Author(s): Priyaranjan Pattanaik, Jayalakshmi Raman and Hemalatha Balaram

Affiliation:

Keywords: plasmodium falciparum, malaria, thiolactomycin, plasmodium enzymes

Abstract: Development of drug resistance by Plasmodium falciparum and insecticide resistance by the mosquito has lead to the resurgence of the most virulent forms of malaria. This review aims to provide a general perspective on drug design for P. falciparum malaria. Though numerous targets have been identified, new clinically useful target-specific inhibitors remain a distant prospect. This review focuses on pathways and enzymes for which some structural information and detailed biochemistry along with specificity of inhibitor action is available. Aspects of the parasite glycolytic pathway, nucleotide metabolism, proteases, redox metabolism and organelle function have been used to highlight possible targets and molecules that could inhibit their function.

Cite this article as:

Pattanaik Priyaranjan, Raman Jayalakshmi and Balaram Hemalatha, Perspectives in Drug Design Against Malaria, Current Topics in Medicinal Chemistry 2002; 2 (5) . https://dx.doi.org/10.2174/1568026024607463