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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Alternative Approaches to the Discovery and Development of Telomerase- Targeted Anticancer Drugs

Author(s): Sara Richter and Manlio Palumbo

Volume 3, Issue 1, 2003

Page: [37 - 49] Pages: 13

DOI: 10.2174/1389557033405511

Price: $65

Abstract

Four different approaches have been reviewed herein: i) nucleoside analogs as mock agents of the reverse transcriptase (hTERT) catalytic site, ii) miscellaneous molecules with unknown mechanism(s) of action, iii) inhibitors of upstream processes of regulation of the hTERT subunit, iiii) immunotherapy against immunogenic hTERT- derived peptides.

Keywords: telomerase, anticancer drug, telomerase inhibitor, htert, mock agents, htert subunit


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