Abstract
Four different approaches have been reviewed herein: i) nucleoside analogs as mock agents of the reverse transcriptase (hTERT) catalytic site, ii) miscellaneous molecules with unknown mechanism(s) of action, iii) inhibitors of upstream processes of regulation of the hTERT subunit, iiii) immunotherapy against immunogenic hTERT- derived peptides.
Keywords: telomerase, anticancer drug, telomerase inhibitor, htert, mock agents, htert subunit
Mini-Reviews in Medicinal Chemistry
Title: Alternative Approaches to the Discovery and Development of Telomerase- Targeted Anticancer Drugs
Volume: 3 Issue: 1
Author(s): Sara Richter and Manlio Palumbo
Affiliation:
Keywords: telomerase, anticancer drug, telomerase inhibitor, htert, mock agents, htert subunit
Abstract: Four different approaches have been reviewed herein: i) nucleoside analogs as mock agents of the reverse transcriptase (hTERT) catalytic site, ii) miscellaneous molecules with unknown mechanism(s) of action, iii) inhibitors of upstream processes of regulation of the hTERT subunit, iiii) immunotherapy against immunogenic hTERT- derived peptides.
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Cite this article as:
Richter Sara and Palumbo Manlio, Alternative Approaches to the Discovery and Development of Telomerase- Targeted Anticancer Drugs, Mini-Reviews in Medicinal Chemistry 2003; 3 (1) . https://dx.doi.org/10.2174/1389557033405511
DOI https://dx.doi.org/10.2174/1389557033405511 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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