Marine Natural Products as Lead Anti-HIV Agents

D.   J.   Gochfeld; K.   A.   El Sayed; M.      Yousaf; J.   F.   Hu; P.      Bartyzel; D.   C.   Dunbar; S.   P.   Wilkins; J.   K.   Zjawiony; R.   F.   Schinazi; S.   Schlueter   Wirtz

doi:10.2174/1389557033487962

Abstract

Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-HIV activity of marine natural products and discuss the efficacy of different structural classes.

Keywords: aids, hiv, marine natural products, structure-activity relationships, modified peptides, alkaloids

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Mini-Reviews in Medicinal Chemistry

Title: Marine Natural Products as Lead Anti-HIV Agents

Volume: 3 Issue: 5

Author(s): D. J. Gochfeld, K. A. El Sayed, M. Yousaf, J. F. Hu, P. Bartyzel, D. C. Dunbar, S. P. Wilkins, J. K. Zjawiony, R. F. Schinazi and S. Schlueter Wirtz

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Keywords: aids, hiv, marine natural products, structure-activity relationships, modified peptides, alkaloids

Abstract: Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-HIV activity of marine natural products and discuss the efficacy of different structural classes.

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Gochfeld J. D., El Sayed A. K., Yousaf M., Hu F. J., Bartyzel P., Dunbar C. D., Wilkins P. S., Zjawiony K. J., Schinazi F. R. and Wirtz Schlueter S., Marine Natural Products as Lead Anti-HIV Agents, Mini-Reviews in Medicinal Chemistry 2003; 3 (5) . https://dx.doi.org/10.2174/1389557033487962