Targeting Focal Adhesion Kinase in Neuroblastoma

Title: Targeting Focal Adhesion Kinase in Neuroblastoma

Volume: 10 Issue: 10

Author(s): Lauren Gillory and Elizabeth A. Beierle

Affiliation:

Keywords: C4, FAK, neuroblastoma, NVP-TAE226, Y15, Cellular Adhesion, VEGFR, MHC, NCAM, MYCN, SKP, chloropyramine hydrochloride, tumor

Abstract: Neuroblastoma is the most common extracranial solid tumor encountered in children, and continues to carry a dismal prognosis. Focal adhesion kinase (FAK) has been shown to be upregulated in a number of human tumors and is related to tumor virulence and patient prognosis. We have demonstrated FAK expression in human neuroblastoma cell lines and tumors, and have shown that FAK is important for neuroblastoma tumor cell viability. We have also demonstrated that FAK inhibition through a number of different methods results in decreased neuroblastoma survival both in vitro and in vivo. The current review addresses the merit of further exploring FAK inhibition as a novel treatment for neuroblastoma.

Cite this article as:

Gillory Lauren and A. Beierle Elizabeth, Targeting Focal Adhesion Kinase in Neuroblastoma, Anti-Cancer Agents in Medicinal Chemistry 2010; 10 (10) . https://dx.doi.org/10.2174/187152010794728684