Cytochrome C is a Hydrogen Peroxide Scavenger in Mitochondria

Zhi-Bo      Wang; Min      Li; Yungang      Zhao; Jian-Xing      Xu

doi:10.2174/0929866033479013

Abstract

The ability of succinate-cytochrome c reductase (SCR) reduced cytochrome c to scavenge H2O2 was investigated. H2O2, whether added or produced by SCR, was efficiently removed when cytochrome c was reduced by SCR. On the other hand, ferrocytochrome c underwent re-oxidization when H2O2 was added. Thus, these results indicate that cytochrome c reduced by succinate-cytochrome c reductase has the ability to regulate H2O2 in mitochondria.

Keywords: cytochrome, hydrogen peroxide, mitochondria, succinate-cytochrome c reductase

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Protein & Peptide Letters

Title: Cytochrome C is a Hydrogen Peroxide Scavenger in Mitochondria

Volume: 10 Issue: 3

Author(s): Zhi-Bo Wang, Min Li, Yungang Zhao and Jian-Xing Xu

Affiliation:

Keywords: cytochrome, hydrogen peroxide, mitochondria, succinate-cytochrome c reductase

Abstract: The ability of succinate-cytochrome c reductase (SCR) reduced cytochrome c to scavenge H2O2 was investigated. H2O2, whether added or produced by SCR, was efficiently removed when cytochrome c was reduced by SCR. On the other hand, ferrocytochrome c underwent re-oxidization when H2O2 was added. Thus, these results indicate that cytochrome c reduced by succinate-cytochrome c reductase has the ability to regulate H2O2 in mitochondria.

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Wang Zhi-Bo, Li Min, Zhao Yungang and Xu Jian-Xing, Cytochrome C is a Hydrogen Peroxide Scavenger in Mitochondria, Protein & Peptide Letters 2003; 10 (3) . https://dx.doi.org/10.2174/0929866033479013