Small Molecules Targeting the NMDA Receptor Complex as Drugs for Neuropathic Pain

Title: Small Molecules Targeting the NMDA Receptor Complex as Drugs for Neuropathic Pain

Volume: 3 Issue: 7

Author(s): Rosa Planells-Cases, Enrique Perez-Paya, Angel Messeguer, Cristina Carreno and Antonio Ferrer-Montiel

Affiliation:

Keywords: excitatory activity, nerve damage, inflammation, ion channels, protein networks, uncompetitive antagonists, synaptic plasticity, drug discovery, pain killers

Abstract: Pain is a complex disease that usually remains poorly treated or undertreated, especially the neuropathic pain caused by injury to the peripheral or central nervous system. Antagonists of the NMDA receptor complex have emerged as potential drugs for pain management. A strong case is being raised for noncompetitive or uncompetitive antagonists with low-to-moderate affinity and fast on / offset kinetics as drugs with good therapeutic profiles, because of their reduced side effects.

Cite this article as:

Planells-Cases Rosa, Perez-Paya Enrique, Messeguer Angel, Carreno Cristina and Ferrer-Montiel Antonio, Small Molecules Targeting the NMDA Receptor Complex as Drugs for Neuropathic Pain, Mini-Reviews in Medicinal Chemistry 2003; 3 (7) . https://dx.doi.org/10.2174/1389557033487782