Abstract
Rhazinilam (1) is a natural substance with unique tubulin-binding properties. The present review describes the isolation and structure elucidation of (1), the available data regarding its biological properties, its semi- and total syntheses and its structure-activity relationships through the synthesis of analogues.
Keywords: rhazinilam, tubulin, structure-activity relationships, semisynthesis, total synthesis, analogues
Mini-Reviews in Organic Chemistry
Title: The Chemistry and Biology of Rhazinilam and Analogues
Volume: 1 Issue: 3
Author(s): Olivier Baudoin, Daniel Guenard and Francoise Gueritte
Affiliation:
Keywords: rhazinilam, tubulin, structure-activity relationships, semisynthesis, total synthesis, analogues
Abstract: Rhazinilam (1) is a natural substance with unique tubulin-binding properties. The present review describes the isolation and structure elucidation of (1), the available data regarding its biological properties, its semi- and total syntheses and its structure-activity relationships through the synthesis of analogues.
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Cite this article as:
Baudoin Olivier, Guenard Daniel and Gueritte Francoise, The Chemistry and Biology of Rhazinilam and Analogues, Mini-Reviews in Organic Chemistry 2004; 1 (3) . https://dx.doi.org/10.2174/1570193043403226
DOI https://dx.doi.org/10.2174/1570193043403226 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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