Ribosome-Inactivating Proteins: Entry into Mammalian Cells and Intracellular Routing

Lynne   M.   Roberts; J.   Michael   Lord

doi:10.2174/1389557043403846

Abstract

To catalytically-modify ribosomes in vivo, ribosome-inactivating proteins produced by plants must enter susceptible mammalian cells in order to reach their substrates in the cytosol. This review primarily focuses on the biosynthesis, mechanism of cell entry and intracellular trafficking of ricin, the most thoroughly studied ribosome-inactivating protein in this respect.

Keywords: ricin, depurination, ribosome, endoplasmic reticulum, retograde transport, retro-translocation

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Mini-Reviews in Medicinal Chemistry

Title: Ribosome-Inactivating Proteins: Entry into Mammalian Cells and Intracellular Routing

Volume: 4 Issue: 5

Author(s): Lynne M. Roberts and J. Michael Lord

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Keywords: ricin, depurination, ribosome, endoplasmic reticulum, retograde transport, retro-translocation

Abstract: To catalytically-modify ribosomes in vivo, ribosome-inactivating proteins produced by plants must enter susceptible mammalian cells in order to reach their substrates in the cytosol. This review primarily focuses on the biosynthesis, mechanism of cell entry and intracellular trafficking of ricin, the most thoroughly studied ribosome-inactivating protein in this respect.

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Roberts M. Lynne and Lord Michael J., Ribosome-Inactivating Proteins: Entry into Mammalian Cells and Intracellular Routing, Mini-Reviews in Medicinal Chemistry 2004; 4 (5) . https://dx.doi.org/10.2174/1389557043403846