Abstract
The first antagonists known for the histamine H3 receptor were mono-substituted imidazolecontaining compounds like thioperamide. Meanwhile numerous novel leads have been developed possessing improved affinities, selectivities, specificities, and pharmacokinetic properties. Scope and limitations of this promising class are discussed concerning their structure-activity relationships as well as pharmacological and potential therapeutic aspects.
Keywords: cipralisant, ciproxifan, clobenpropit, h3 receptor, imidazole, sch 79687, radioligand, thioperamide
Mini-Reviews in Medicinal Chemistry
Title: Medicinal Chemical and Pharmacological Aspects of Imidazole-Containing Histamine H3 Receptor Antagonists
Volume: 4 Issue: 9
Author(s): Holger Stark, Markus Kathmann, Eberhard Schlicker, Walter Schunack, Birgit Schlegel and Wolfgang Sippl
Affiliation:
Keywords: cipralisant, ciproxifan, clobenpropit, h3 receptor, imidazole, sch 79687, radioligand, thioperamide
Abstract: The first antagonists known for the histamine H3 receptor were mono-substituted imidazolecontaining compounds like thioperamide. Meanwhile numerous novel leads have been developed possessing improved affinities, selectivities, specificities, and pharmacokinetic properties. Scope and limitations of this promising class are discussed concerning their structure-activity relationships as well as pharmacological and potential therapeutic aspects.
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Cite this article as:
Stark Holger, Kathmann Markus, Schlicker Eberhard, Schunack Walter, Schlegel Birgit and Sippl Wolfgang, Medicinal Chemical and Pharmacological Aspects of Imidazole-Containing Histamine H3 Receptor Antagonists, Mini-Reviews in Medicinal Chemistry 2004; 4 (9) . https://dx.doi.org/10.2174/1389557043403107
DOI https://dx.doi.org/10.2174/1389557043403107 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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