Inhibitors Targeting the Enzymatic Activity and Biological Function of Pin1

Yixin      Zhang

doi:10.2174/1570193043403055

Abstract

Pin1, a phospho-Ser / Thr-Pro specific PPIase, participates in many biological processes. Recently, through designing substrate mimetics, or library screening, several classes of Pin1 inhibitors have been discovered. Some polyaromatic compounds, including juglone, as well as peptide mimetics containing both proline and phosphate, have been demonstrated to inhibit biological functions of Pin1.

Keywords: pin1, inhibitor, ppiase, substrate mimetics, combinatorial library, phosphorylation

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Mini-Reviews in Organic Chemistry

Title: Inhibitors Targeting the Enzymatic Activity and Biological Function of Pin1

Volume: 1 Issue: 4

Author(s): Yixin Zhang

Affiliation:

Keywords: pin1, inhibitor, ppiase, substrate mimetics, combinatorial library, phosphorylation

Abstract: Pin1, a phospho-Ser / Thr-Pro specific PPIase, participates in many biological processes. Recently, through designing substrate mimetics, or library screening, several classes of Pin1 inhibitors have been discovered. Some polyaromatic compounds, including juglone, as well as peptide mimetics containing both proline and phosphate, have been demonstrated to inhibit biological functions of Pin1.

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Zhang Yixin, Inhibitors Targeting the Enzymatic Activity and Biological Function of Pin1, Mini-Reviews in Organic Chemistry 2004; 1 (4) . https://dx.doi.org/10.2174/1570193043403055