Predicting Synthetic Accessibility: Application in Drug Discovery and Development

J.   C.   Baber; M.      Feher

doi:10.2174/1389557043403765

Abstract

The estimation and use of synthetic accessibility in the drug discovery process is discussed. A distinction is drawn between synthetic feasibility and accessibility and the practical uses of an accessibility score are examined. Various techniques used in the estimation of accessibility are described and their utility and potential accuracy compared.

Keywords: synthetic accessibility, synthetic feasibility, drug discovery, drug development, screening, prioritization, retrosynthetic analysis

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Mini-Reviews in Medicinal Chemistry

Title: Predicting Synthetic Accessibility: Application in Drug Discovery and Development

Volume: 4 Issue: 6

Author(s): J. C. Baber and M. Feher

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Keywords: synthetic accessibility, synthetic feasibility, drug discovery, drug development, screening, prioritization, retrosynthetic analysis

Abstract: The estimation and use of synthetic accessibility in the drug discovery process is discussed. A distinction is drawn between synthetic feasibility and accessibility and the practical uses of an accessibility score are examined. Various techniques used in the estimation of accessibility are described and their utility and potential accuracy compared.

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Baber C. J. and Feher M., Predicting Synthetic Accessibility: Application in Drug Discovery and Development, Mini-Reviews in Medicinal Chemistry 2004; 4 (6) . https://dx.doi.org/10.2174/1389557043403765