Abstract
Cyclooxygenases and lipoxygenase are key enzymes in the arachidonic acid metabolism. Dual inhibitors are drugs able to block both the COX and the 5-LOX metabolic pathways. Compared to COX or LOX pathways single inhibitors, dual inhibitors present at least two major advantages. First, dual inhibitors, by acting on the two major arachidonic acid metabolic pathways, possess a wide range of anti-inflammatory activities. Secondly, dual inhibitors appear to be almost exempt from gastric toxicity, which is the most troublesome side effect of non-selective COX inhibitors.
Keywords: cancer, cyclooxygenases, dual inhibitors, inflammation, leukotrienes
Mini-Reviews in Medicinal Chemistry
Title: Recent Development in the Field of Dual COX / 5-LOX Inhibitors
Volume: 4 Issue: 6
Author(s): Fabien Julemont, Jean-Michel Dogne, Bernard Pirotte and Xavier de Leval
Affiliation:
Keywords: cancer, cyclooxygenases, dual inhibitors, inflammation, leukotrienes
Abstract: Cyclooxygenases and lipoxygenase are key enzymes in the arachidonic acid metabolism. Dual inhibitors are drugs able to block both the COX and the 5-LOX metabolic pathways. Compared to COX or LOX pathways single inhibitors, dual inhibitors present at least two major advantages. First, dual inhibitors, by acting on the two major arachidonic acid metabolic pathways, possess a wide range of anti-inflammatory activities. Secondly, dual inhibitors appear to be almost exempt from gastric toxicity, which is the most troublesome side effect of non-selective COX inhibitors.
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Cite this article as:
Julemont Fabien, Dogne Jean-Michel, Pirotte Bernard and Leval de Xavier, Recent Development in the Field of Dual COX / 5-LOX Inhibitors, Mini-Reviews in Medicinal Chemistry 2004; 4 (6) . https://dx.doi.org/10.2174/1389557043403747
DOI https://dx.doi.org/10.2174/1389557043403747 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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