Biomacromolecule Surface Recognition Using Nanoparticles

Catherine   M.   Goodman; Vincent   M.   Rotello

doi:10.2174/1570193043488935

Abstract

Monolayer-protected nanoparticles represent a new class of receptors, capable of high affinity, multivalent binding with biomolecules. Networks of self-optimizing bioactive substituents can be introduced via facile place-exchange of functionalized thiols, approximating the diversified topology of biological surfaces. Extension of these particles to model systems and in catalysis is described.

Keywords: noncovalent interactions, nanoparticle, monolayer-protected clusters, biomolecular recognition

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Mini-Reviews in Organic Chemistry

Title: Biomacromolecule Surface Recognition Using Nanoparticles

Volume: 1 Issue: 1

Author(s): Catherine M. Goodman and Vincent M. Rotello

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Keywords: noncovalent interactions, nanoparticle, monolayer-protected clusters, biomolecular recognition

Abstract: Monolayer-protected nanoparticles represent a new class of receptors, capable of high affinity, multivalent binding with biomolecules. Networks of self-optimizing bioactive substituents can be introduced via facile place-exchange of functionalized thiols, approximating the diversified topology of biological surfaces. Extension of these particles to model systems and in catalysis is described.

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Goodman M. Catherine and Rotello M. Vincent, Biomacromolecule Surface Recognition Using Nanoparticles, Mini-Reviews in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570193043488935