Design and Cytotoxicity Analysis of a Conjugate Containing the New DGalactose- Binding Lectin SELld and the Non-Toxic Type 2 Ribosome- Inactivating Protein Nigrin b

Title: Design and Cytotoxicity Analysis of a Conjugate Containing the New DGalactose- Binding Lectin SELld and the Non-Toxic Type 2 Ribosome- Inactivating Protein Nigrin b

Volume: 1 Issue: 4

Author(s): Jorge Benitez, M. Angeles Rojo, Raquel Munoz, J. Miguel Ferreras, Pilar Jimenez and Tomas Girbes

Affiliation:

Keywords: nigrin b, selld, ribosome-inactivating proteins, colo 320 cells, cancer therapy, apoptosis

Abstract: Conjugates containing nigrin b (two-chain RIP) linked to a new lectin (SELld) from Sambucus ebulus L. have been designed. They retain the anti-ribosomal inhibitory activity of nigrin b but, in contrast to nigrin b, they exerted strong cytotoxicity on COLO 320 and HeLa cells, which ran in parallel with DNA fragmentation.

Cite this article as:

Benitez Jorge, Rojo Angeles M., Munoz Raquel, Ferreras Miguel J., Jimenez Pilar and Girbes Tomas, Design and Cytotoxicity Analysis of a Conjugate Containing the New DGalactose- Binding Lectin SELld and the Non-Toxic Type 2 Ribosome- Inactivating Protein Nigrin b, Letters in Drug Design & Discovery 2004; 1 (4) . https://dx.doi.org/10.2174/1570180043398687