Mild and Most Efficient Silylcyanation of Aldehydes Catalyzed by Cesium Fluoride

Sung   Soo   Kim; Dae   Ho   Song

doi:10.2174/1570178043400884

Abstract

Cesium fluoride (CsF) catalyzes the addition of trimethylsilyl cyanide (TMSCN) to various aldehydes. Aromatic, aliphatic, cyclic and heterocyclic aldehydes have been converted into the corresponding trimethylsilyl ethers. Most of the aldehydes show over 99% yield for 20min. The mechanism of silylcyanation has been proposed.

Keywords: silylcyanation, aldehydes, tmscn, cesium fluoride

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Letters in Organic Chemistry

Title: Mild and Most Efficient Silylcyanation of Aldehydes Catalyzed by Cesium Fluoride

Volume: 1 Issue: 3

Author(s): Sung Soo Kim and Dae Ho Song

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Keywords: silylcyanation, aldehydes, tmscn, cesium fluoride

Abstract: Cesium fluoride (CsF) catalyzes the addition of trimethylsilyl cyanide (TMSCN) to various aldehydes. Aromatic, aliphatic, cyclic and heterocyclic aldehydes have been converted into the corresponding trimethylsilyl ethers. Most of the aldehydes show over 99% yield for 20min. The mechanism of silylcyanation has been proposed.

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Kim Soo Sung and Song Ho Dae, Mild and Most Efficient Silylcyanation of Aldehydes Catalyzed by Cesium Fluoride, Letters in Organic Chemistry 2004; 1 (3) . https://dx.doi.org/10.2174/1570178043400884