Development of Radioligands for In Vivo Imaging of GABAA-Benzodiazepine Receptors

Title: Development of Radioligands for In Vivo Imaging of GABAA-Benzodiazepine Receptors

Volume: 4 Issue: 8

Author(s): Andrew Katsifis and Michael Kassiou

Affiliation:

Keywords: benzodiazepines, cns receptors, radioligands, pet, spect

Abstract: Changes in the biochemical integrity and function of the GABAA-benzodiazepine receptor (BZR) complex have been implicated in various neurological and psychiatric disorders. The development of specific radioligands for the GABAA-BZR have not only contributed to the elucidation of the receptors biochemical functions, but also provided a means by which these changes are correlated to disease states when studied with the functional imaging modalities of positron emission tomography (PET) and single photon emission computed tomography (SPECT).

Cite this article as:

Katsifis Andrew and Kassiou Michael, Development of Radioligands for In Vivo Imaging of GABAA-Benzodiazepine Receptors, Mini-Reviews in Medicinal Chemistry 2004; 4 (8) . https://dx.doi.org/10.2174/1389557043403332