Designing a Pronucleotide Stratagem: Lessons from Amino Acid Phosphoramidates of Anticancer and Antiviral Pyrimidines

Title: Designing a Pronucleotide Stratagem: Lessons from Amino Acid Phosphoramidates of Anticancer and Antiviral Pyrimidines

Volume: 4 Issue: 4

Author(s): Dan P. Drontle and Carston R. Wagner

Affiliation:

Keywords: pronucleotide stratagem, phosphoramidates, antiviral pyrimidines, nucleoside monophosphates

Abstract: Phosphoramidate pronucleotides have proven to be an effective strategy for the intracellular delivery of nucleoside 5-monophosphates. This review will summarize our efforts to understand the in vitro and in vivo behavior of phosphoramidate monoesters of 3-azido-3-deoxythymidine (AZT), 3-fluoro-3- deoxythymidine (FLT) and 5-fluoro-2-deoxyuridine (FUdR). Insights drawn from these studies have proved valuable for the future design of phosphoramidate-based pronucleotides.

Cite this article as:

Drontle P. Dan and Wagner R. Carston, Designing a Pronucleotide Stratagem: Lessons from Amino Acid Phosphoramidates of Anticancer and Antiviral Pyrimidines, Mini-Reviews in Medicinal Chemistry 2004; 4 (4) . https://dx.doi.org/10.2174/1389557043403945