Amide Mono Thioxylated Derivatives of MEN 10627

M.      Altamura; G.      Balacco; A.      Giolitti; A.      Guidi; R.      Patacchini; A.   R.   Renzetti; A.      Triolo; C.   A.   Maggi

doi:10.2174/1570180043398966

Abstract

The thioxylation of the potent Neurokinin A antagonist MEN 10627 by Lawessons reagent showed to be potentially useful for the post-synthetic manipulation of the related family of structurally peculiar bicyclic hexapeptides, whose synthesis in combinatorial manner has been recently described.

Keywords: tachykinins, thiopeptides, thioxopeptides, lawesson reagent, atp, anti-ischaemic drugs

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Letters in Drug Design & Discovery

Title: Amide Mono Thioxylated Derivatives of MEN 10627

Volume: 1 Issue: 3

Author(s): M. Altamura, G. Balacco, A. Giolitti, A. Guidi, R. Patacchini, A. R. Renzetti, A. Triolo and C. A. Maggi

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Keywords: tachykinins, thiopeptides, thioxopeptides, lawesson reagent, atp, anti-ischaemic drugs

Abstract: The thioxylation of the potent Neurokinin A antagonist MEN 10627 by Lawessons reagent showed to be potentially useful for the post-synthetic manipulation of the related family of structurally peculiar bicyclic hexapeptides, whose synthesis in combinatorial manner has been recently described.

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Altamura M., Balacco G., Giolitti A., Guidi A., Patacchini R., Renzetti R. A., Triolo A. and Maggi A. C., Amide Mono Thioxylated Derivatives of MEN 10627, Letters in Drug Design & Discovery 2004; 1 (3) . https://dx.doi.org/10.2174/1570180043398966