Abstract
A novel gene modulation system was identified within mammalian introns, regulating intracellular gene transcripts homologous to certain 5-proximal non-snRNP-binding regions of spliced introns. This gene modulation system can be manipulated for the analysis of gene function and development of gene-specific therapeutics, using artificial introns with 5-proximal hairpin inserts.
Keywords: artificial intron, posttranscriptional gene silencing, pol-II-directed rna interference (rnai), d-rnai, mirna generation, rna splicing, intron-mediated enhancement (ime)
Letters in Drug Design & Discovery
Title: New Drug Design for Gene Therapy - Taking Advantage of Introns
Volume: 1 Issue: 3
Author(s): Shi-Lung Lin and Shao-Yao Ying
Affiliation:
Keywords: artificial intron, posttranscriptional gene silencing, pol-II-directed rna interference (rnai), d-rnai, mirna generation, rna splicing, intron-mediated enhancement (ime)
Abstract: A novel gene modulation system was identified within mammalian introns, regulating intracellular gene transcripts homologous to certain 5-proximal non-snRNP-binding regions of spliced introns. This gene modulation system can be manipulated for the analysis of gene function and development of gene-specific therapeutics, using artificial introns with 5-proximal hairpin inserts.
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Cite this article as:
Lin Shi-Lung and Ying Shao-Yao, New Drug Design for Gene Therapy - Taking Advantage of Introns, Letters in Drug Design & Discovery 2004; 1 (3) . https://dx.doi.org/10.2174/1570180043398939
DOI https://dx.doi.org/10.2174/1570180043398939 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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