Some Observations on the Preparation of Amides and their Reduction to Amines in Ionic Liquids

Lucia   Raffaella   Lampariello; Daniela      Peruzzi; Alessandro      Sega; Maurizio      Taddei

doi:10.2174/1570178053765230

Abstract

The preparation of amides in ionic liquids was explored using the Schotten-Baumann procedure,the Weinreb amidation of esters and the classical coupling reaction using EDC,HBTU or DMTMM as the coupling agents.In any case amides were obtained in comparable or better yields and with a simplified procedure than using conventional solvents.Moreover,the amides were directly reduced in the same flask to the corresponding secondary or tertiary amines by heating in the presence of solid sodium borohydride.

Keywords: amides, amines, ionic liquids, reduction

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Letters in Organic Chemistry

Title: Some Observations on the Preparation of Amides and their Reduction to Amines in Ionic Liquids

Volume: 2 Issue: 3

Author(s): Lucia Raffaella Lampariello, Daniela Peruzzi, Alessandro Sega and Maurizio Taddei

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Keywords: amides, amines, ionic liquids, reduction

Abstract: The preparation of amides in ionic liquids was explored using the Schotten-Baumann procedure,the Weinreb amidation of esters and the classical coupling reaction using EDC,HBTU or DMTMM as the coupling agents.In any case amides were obtained in comparable or better yields and with a simplified procedure than using conventional solvents.Moreover,the amides were directly reduced in the same flask to the corresponding secondary or tertiary amines by heating in the presence of solid sodium borohydride.

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Lampariello Raffaella Lucia, Peruzzi Daniela, Sega Alessandro and Taddei Maurizio, Some Observations on the Preparation of Amides and their Reduction to Amines in Ionic Liquids, Letters in Organic Chemistry 2005; 2 (3) . https://dx.doi.org/10.2174/1570178053765230