Mannich-type Reaction of Methylene Active Compounds with a Chiral Sulfinimine of Trifluoropyruvate: New Highly Stereoselective Synthesis of (S)-α-Trifluoromethyl-Aspartic Acid

Francesco      Lazzaro; Arnaud      Gissot; Marcello      Crucianelli; Francesco   De   Angelis; Luca      Bruche; Matteo      Zanda

doi:10.2174/1570178053765348

Abstract

A strongly improved, highly stereoselective synthesis of (S)-α-trifluoromethyl aspartic acid via addition of lithium malonate to a chiral sulfinimine of trifluoropyruvate is presented.

Keywords: fluorine, sulfinimines, mannich-reaction, trifluoromethyl amino acids, stereoselective synthesis

« Previous Next »

Rights & Permissions Print Cite

Letters in Organic Chemistry

Title: Mannich-type Reaction of Methylene Active Compounds with a Chiral Sulfinimine of Trifluoropyruvate: New Highly Stereoselective Synthesis of (S)-α-Trifluoromethyl-Aspartic Acid

Volume: 2 Issue: 3

Author(s): Francesco Lazzaro, Arnaud Gissot, Marcello Crucianelli, Francesco De Angelis, Luca Bruche and Matteo Zanda

Affiliation:

Keywords: fluorine, sulfinimines, mannich-reaction, trifluoromethyl amino acids, stereoselective synthesis

Abstract: A strongly improved, highly stereoselective synthesis of (S)-α-trifluoromethyl aspartic acid via addition of lithium malonate to a chiral sulfinimine of trifluoropyruvate is presented.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Lazzaro Francesco, Gissot Arnaud, Crucianelli Marcello, Angelis De Francesco, Bruche Luca and Zanda Matteo, Mannich-type Reaction of Methylene Active Compounds with a Chiral Sulfinimine of Trifluoropyruvate: New Highly Stereoselective Synthesis of (S)-α-Trifluoromethyl-Aspartic Acid, Letters in Organic Chemistry 2005; 2 (3) . https://dx.doi.org/10.2174/1570178053765348