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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Pharmacological Comparison of Two Different Insect Models Using the Scorpion α-Like Toxin BmK M1 from Buthus martensii Karsch

Author(s): Frank Bosmans, Bert Brone, Yan-Mei Sun, Rong-Huan Zhu, Yu-Mei Xiong, Da-Cheng Wang, Emmy Van Kerkhove and Jan Tytgat

Volume 12, Issue 4, 2005

Page: [363 - 367] Pages: 5

DOI: 10.2174/0929866053765635

Price: $65

Abstract

In this study, the effect of the scorpion a-like toxin BmK M1 was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na+ channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding α-like toxins. Moreover, with the aid of the α-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown.

Keywords: bmkm, voltage-gated na channels, locust dum neurons, para/tipe


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