Abstract
The p38 kinase plays a central role in inflammation, and it has been the subject of extensive efforts in both basic research and drug discovery. This review summarizes the biology of the p38 kinase with a focus on its role in inflammation. The p38 kinase regulates the production of key inflammatory mediators, including TNFα, IL-1β, and COX- 2. In addition, p38 also acts downstream of cytokines such as TNFα, mediating some of their effects. The potential efficacy of p38 inhibitors may thus be greater than would be expected from the inhibition of the mediators alone. Inhibitors of p38 kinase are currently in development for the treatment of rheumatoid arthritis. The biological processes regulated by p38 kinase suggest a wide variety of additional potential indications.
Keywords: inflammatory mediators, cox, nsaid, p signal transduction, mapkap, monocyte chemotactic protein (mcp)
Current Topics in Medicinal Chemistry
Title: The Biology of p38 Kinase: A Central Role in Inflammation
Volume: 5 Issue: 10
Author(s): Gary L. Schieven
Affiliation:
Keywords: inflammatory mediators, cox, nsaid, p signal transduction, mapkap, monocyte chemotactic protein (mcp)
Abstract: The p38 kinase plays a central role in inflammation, and it has been the subject of extensive efforts in both basic research and drug discovery. This review summarizes the biology of the p38 kinase with a focus on its role in inflammation. The p38 kinase regulates the production of key inflammatory mediators, including TNFα, IL-1β, and COX- 2. In addition, p38 also acts downstream of cytokines such as TNFα, mediating some of their effects. The potential efficacy of p38 inhibitors may thus be greater than would be expected from the inhibition of the mediators alone. Inhibitors of p38 kinase are currently in development for the treatment of rheumatoid arthritis. The biological processes regulated by p38 kinase suggest a wide variety of additional potential indications.
Export Options
About this article
Cite this article as:
Schieven L. Gary, The Biology of p38 Kinase: A Central Role in Inflammation, Current Topics in Medicinal Chemistry 2005; 5 (10) . https://dx.doi.org/10.2174/1568026054985902
DOI https://dx.doi.org/10.2174/1568026054985902 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Neurobiology and Genetics of Behavioural Syndromes of Alzheimers Disease
Current Alzheimer Research Rational Targeting of the Urokinase Receptor (uPAR): Development of Antagonists and Non-Invasive Imaging Probes
Current Drug Targets Controversies in Anticoagulant Therapy in Vitreo-Retinal Surgery
Current Pharmaceutical Design Auto-Antibodies As Possible Markers and Mediators of Ischemic, Dilated, and Rhythmic Cardiopathies
Current Drug Targets Venous Thromboembolism Risk and Adequacy of Prophylaxis in High Risk Pregnancy in the Arabian Gulf
Current Vascular Pharmacology RNA Interference-Mediated Validation of Survivin and Apollon/BRUCE as New Therapeutic Targets for Cancer Therapy
Current Topics in Medicinal Chemistry Advances in Clinical Study of Curcumin
Current Pharmaceutical Design Editorial (Thematic Issue: Antiinflammatory Treatment for Seemingly Non-inflammatory Disorders-Part 2)
Endocrine, Metabolic & Immune Disorders - Drug Targets Interaction Between Bone and Muscle in Older Persons with Mobility Limitations
Current Pharmaceutical Design CRF Receptor Antagonists: Utility in Research and Clinical Practice
Current Medicinal Chemistry Endotherapia
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Synthesis of some 1H-1,5-benzodiazepine Series Containing Chromene Ring from α,β-Unsaturated Ketones of 6-Acetyl-5-Hydroxy-4-Methylcoumarin
Current Organic Synthesis Cellular Signaling in Cartilage Tissue Engineering
Current Signal Transduction Therapy Systemic Approach to the Study of Complex Bone Disorders at the Whole- Genome Level
Current Genomics Application of High Hydrostatic Pressure to Dissociate Aggregates and Refold Proteins
Current Pharmaceutical Biotechnology Elicitation of Immune Responsiveness Against Antigenic Challenge in Age- Related Diseases: Effects of Red Wine Polyphenols
Current Pharmaceutical Design The Effect of Anti-B-cell Therapy on the Development of Atherosclerosis in Patients with Rheumatoid Arthritis
Current Pharmaceutical Design Features of Undifferentiated Spondyloarthropathy and Juvenile Spondyloarthropathy Among Asian Populations
Current Rheumatology Reviews Molecular Design and Clinical Development of VEGFR Kinase Inhibitors
Current Topics in Medicinal Chemistry Targeting the Coagulation Factor Fibrinogen for Arthritis Therapy
Current Pharmaceutical Biotechnology