Bakers Yeast Reduction of PEG-Linked Acetoacetate

G.   M.   Bonora; S.      Drioli; C.      Forzato; P.      Nitti; G.      Pitacco

doi:10.2174/1570178053400135

Abstract

Bioreduction of PEG-acetoacetate 1 is achieved using dry bakers yeast in toluene with a small amount of added water. After detachment from the polymer under basic conditions, the corresponding (S)-(+)- 3-hydroxybutanoic acid 3 was esterified with Me3SiCl and ethanol and ethyl (S)-(+)-3-hydroxybutanoate 4 was isolated with 97% e.e. and 70% overall yield.

Keywords: baker yeast, bioreduction, organic solvent, peg

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Letters in Organic Chemistry

Title: Bakers Yeast Reduction of PEG-Linked Acetoacetate

Volume: 2 Issue: 1

Author(s): G. M. Bonora, S. Drioli, C. Forzato, P. Nitti and G. Pitacco

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Keywords: baker yeast, bioreduction, organic solvent, peg

Abstract: Bioreduction of PEG-acetoacetate 1 is achieved using dry bakers yeast in toluene with a small amount of added water. After detachment from the polymer under basic conditions, the corresponding (S)-(+)- 3-hydroxybutanoic acid 3 was esterified with Me3SiCl and ethanol and ethyl (S)-(+)-3-hydroxybutanoate 4 was isolated with 97% e.e. and 70% overall yield.

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Bonora M. G., Drioli S., Forzato C., Nitti P. and Pitacco G., Bakers Yeast Reduction of PEG-Linked Acetoacetate, Letters in Organic Chemistry 2005; 2 (1) . https://dx.doi.org/10.2174/1570178053400135