Chemoselective Carbonyl Benzylation Mediated by Zn / CdCl2 / InCl3 in Tap Water

Cunliu      Zhou; Jiaoyang      Jiang; Yuqing      Zhou; Zhen      Xie; Qian      Miao; Zhiyong      Wang

doi:10.2174/1570178053400072

Abstract

A novel tri-metal system (Zn / CdCl2 / InCl3) has been developed as an effective mediator in the benzylations of various aldehydes in tap water to afford the corresponding alcohols. It can selectively mediate the benzylation of aldehyde in the presence of ketone. CdCl2 and InCl3 are easily recycled and used in this reaction without further purification.

Keywords: chemoselective addition, water, barbier reaction, benzylation, carbonyl compound, tri-metal system

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Letters in Organic Chemistry

Title: Chemoselective Carbonyl Benzylation Mediated by Zn / CdCl2 / InCl3 in Tap Water

Volume: 2 Issue: 1

Author(s): Cunliu Zhou, Jiaoyang Jiang, Yuqing Zhou, Zhen Xie, Qian Miao and Zhiyong Wang

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Keywords: chemoselective addition, water, barbier reaction, benzylation, carbonyl compound, tri-metal system

Abstract: A novel tri-metal system (Zn / CdCl2 / InCl3) has been developed as an effective mediator in the benzylations of various aldehydes in tap water to afford the corresponding alcohols. It can selectively mediate the benzylation of aldehyde in the presence of ketone. CdCl2 and InCl3 are easily recycled and used in this reaction without further purification.

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Zhou Cunliu, Jiang Jiaoyang, Zhou Yuqing, Xie Zhen, Miao Qian and Wang Zhiyong, Chemoselective Carbonyl Benzylation Mediated by Zn / CdCl2 / InCl3 in Tap Water, Letters in Organic Chemistry 2005; 2 (1) . https://dx.doi.org/10.2174/1570178053400072