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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis and Transformations of New Spiro-4-piperidines. Acetyl Migration in 1-Acetyl-1-Benzyl-4-Methyl-3,4-Dihydrospiro[(1H)quinoline-2,4-piperidines] Under Debenzylation Conditions

Author(s): Vladimir V. Kouznetsov, Basilio Diaz P., Clara Marcela Sanabria M., Leonor Y. Vargas M., Juan Carlos Poveda, Elena E. Stashenko, Alí Bahsas and Juan Amaro-Luis

Volume 2, Issue 1, 2005

Page: [29 - 32] Pages: 4

DOI: 10.2174/1570178053400234

Price: $65

Abstract

Synthesis of new dihydrospiro[quinoline-2,4-piperidines] by a two-step synthetic route based on 4-piperidone imine reactivity is reported. An acetyl migration in 1-acetyl-1-benzyl-4-methyl-3,4- dihydrospiro[quinoline-2,4-piperidines] under debenzylation conditions (HCOONH4 / Pd / C / MeOH) is found.

Keywords: spiropiperidines, intramolecular alkene friedel-crafts alkylation, debenzylation, acetyl migration


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