Abstract
During the last decade an increasing number of reports describe the roles of active oxygen species in the development or exacerbation of various kinds of diseases. Antioxidants are of great interest because of their involvement in important biological and industrial processes. They have been found to possess anticancer, anti-cardiovascular, anti-inflammatory and many other activities. Many attempts have been made to elucidate the QSAR of antioxidants by using different physicochemical parameters. Unfortunately the limited number of antioxidants and the unavailable σ Hammett values of complex substituents did not lead to significant results in regression analysis. The redox potentials are well correlated to the antioxidant activities. In this report we will attempt to collect and discuss all the published results concerning the QSAR research on natural and synthetic antioxidants compounds.
Keywords: qsar, natural and synthetic antioxidants, electronic effects
Mini-Reviews in Medicinal Chemistry
Title: A Review on Quantitative Structure-Activity Relationships (QSARs) of Natural and Synthetic Antioxidants Compounds
Volume: 5 Issue: 6
Author(s): A. C. Kontogiorgis, A. E. Pontiki and D. Hadjipavlou-Litina
Affiliation:
Keywords: qsar, natural and synthetic antioxidants, electronic effects
Abstract: During the last decade an increasing number of reports describe the roles of active oxygen species in the development or exacerbation of various kinds of diseases. Antioxidants are of great interest because of their involvement in important biological and industrial processes. They have been found to possess anticancer, anti-cardiovascular, anti-inflammatory and many other activities. Many attempts have been made to elucidate the QSAR of antioxidants by using different physicochemical parameters. Unfortunately the limited number of antioxidants and the unavailable σ Hammett values of complex substituents did not lead to significant results in regression analysis. The redox potentials are well correlated to the antioxidant activities. In this report we will attempt to collect and discuss all the published results concerning the QSAR research on natural and synthetic antioxidants compounds.
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Cite this article as:
Kontogiorgis C. A., Pontiki E. A. and Hadjipavlou-Litina D., A Review on Quantitative Structure-Activity Relationships (QSARs) of Natural and Synthetic Antioxidants Compounds, Mini-Reviews in Medicinal Chemistry 2005; 5 (6) . https://dx.doi.org/10.2174/1389557054023233
DOI https://dx.doi.org/10.2174/1389557054023233 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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