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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Characterization of a Novel Protein Tyrosine Phosphatase Inhibitor, 2-(Cyclobutylamino)- N- (2-Furylmethyl)-2-Thioxoacetamide

Author(s): Y. Kobayashi-Matsunaga, T. Ishii, T. Hamaguchi, H. Osada and M. Sato

Volume 2, Issue 3, 2005

Page: [224 - 227] Pages: 4

DOI: 10.2174/1570180053765101

Price: $65

Abstract

The synthesis and biological activities of a series of 2-amino-2-thioxoacetamide derivatives are described. These compounds have inhibitory effects against the protein tyrosine phosphatase activity of CD45. Compound 4i inhibited the PCA reaction in vivo.

Keywords: protein tyrosine phosphatase inhibitor, cd, thioxoacetamide


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