A Mild and Efficient Synthesis of Disecondary Phosphines Using CsOH: Efforts Toward Phosphine Macrocycles

Title: A Mild and Efficient Synthesis of Disecondary Phosphines Using CsOH: Efforts Toward Phosphine Macrocycles

Volume: 2 Issue: 2

Author(s): Matthew T. Honaker and Ralph N. Salvatore

Affiliation:

Keywords: primary phosphine, cesium hydroxide monohydrate, dialkyl halide, disecondary phosphine, phosphine macrocycle

Abstract: A mild and improved synthesis of disecondary phosphines PhPH(CH2)nPHPh (where n = 1-6), have been prepared. In the presence of phenylphosphine, cesium hydroxide, activated 4 Å molecular sieves and DMF, numerous dialkyl halides reacted efficiently to produce various disecondary phosphines exclusively at room temperature.

Cite this article as:

Honaker T. Matthew and Salvatore N. Ralph, A Mild and Efficient Synthesis of Disecondary Phosphines Using CsOH: Efforts Toward Phosphine Macrocycles, Letters in Organic Chemistry 2005; 2 (2) . https://dx.doi.org/10.2174/1570178053202874