Abstract
A privileged structure has been identified within the 1,300-member diversified library by rational selection of the compounds to be tested prior to the screening towards enzymatic β-secretase (BACE-1) assay. The identified hexahydrobenzothiazole privileged structure has been optimised and a preliminary structureactivity study has been performed.
Keywords: Diversified chemical library, screening, privileged structure, β-secretase (BACE-1), Alzheimer's disease, hexahydrobenzothiazole