Identification of Privileged Scaffolds from a Diversified Chemical Library forβ-Secretase Inhibition

Title: Identification of Privileged Scaffolds from a Diversified Chemical Library forβ-Secretase Inhibition

Volume: 2 Issue: 8

Author(s): Nicolas Pietrancosta, Gilles Quelever, Cedrik Garino, Younes Laras, Stephane Burlet and Jean-Louis Kraus

Affiliation:

Keywords: Diversified chemical library, screening, privileged structure, β-secretase (BACE-1), Alzheimer's disease, hexahydrobenzothiazole

Abstract: A privileged structure has been identified within the 1,300-member diversified library by rational selection of the compounds to be tested prior to the screening towards enzymatic β-secretase (BACE-1) assay. The identified hexahydrobenzothiazole privileged structure has been optimised and a preliminary structureactivity study has been performed.

Cite this article as:

Pietrancosta Nicolas, Quelever Gilles, Garino Cedrik, Laras Younes, Burlet Stephane and Kraus Jean-Louis, Identification of Privileged Scaffolds from a Diversified Chemical Library forβ-Secretase Inhibition, Letters in Drug Design & Discovery 2005; 2 (8) . https://dx.doi.org/10.2174/157018005774717352