The Brown Adipose Cell: A Unique Model for Understanding the Molecular Mechanism of Insulin Resistance

Title: The Brown Adipose Cell: A Unique Model for Understanding the Molecular Mechanism of Insulin Resistance

Volume: 5 Issue: 3

Author(s): Angela M. Valverde and Manuel Benito

Affiliation:

Keywords: brown adipocytes, insulin signaling, insulin resistance, insulin receptor, insulin receptor substrates, adipocyte differentiation

Abstract: Type 2 diabetes mellitus (NIDDM) is a complex metabolic disease that occurs when insulin secretion can no longer compensate insulin resistance in peripheral tissues. At the molecular level, insulin resistance correlates with impaired insulin signaling. This review provides new insights into the molecular mechanisms of insulin action and resistance in brown adipose tissue (BAT) and pinpoints the role of BAT in the control of glucose homeostasis.

Cite this article as:

Valverde M. Angela and Benito Manuel, The Brown Adipose Cell: A Unique Model for Understanding the Molecular Mechanism of Insulin Resistance, Mini-Reviews in Medicinal Chemistry 2005; 5 (3) . https://dx.doi.org/10.2174/1389557053175380