Current Status and Future Possibilities of Nitric Oxide-Donor Drugs: Focus on S-Nitrosothiols

H.   H.   Al-Sa'doni; A.      Ferro

doi:10.2174/1389557053175399

Abstract

Drugs which release nitric oxide (NO) have great therapeutic potential. The organic nitrates and sodium nitroprusside have been used in cardiovascular therapeutics for many years, but several drawbacks limit their usefulness. In this review, we consider novel and potential future developments in NO-donor drugs, and the possible clinical usefulness of such compounds.

Keywords: nitric oxide, nitric oxide donors, s-nitrosothiols, therapeutics

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Mini-Reviews in Medicinal Chemistry

Title: Current Status and Future Possibilities of Nitric Oxide-Donor Drugs: Focus on S-Nitrosothiols

Volume: 5 Issue: 3

Author(s): H. H. Al-Sa'doni and A. Ferro

Affiliation:

Keywords: nitric oxide, nitric oxide donors, s-nitrosothiols, therapeutics

Abstract: Drugs which release nitric oxide (NO) have great therapeutic potential. The organic nitrates and sodium nitroprusside have been used in cardiovascular therapeutics for many years, but several drawbacks limit their usefulness. In this review, we consider novel and potential future developments in NO-donor drugs, and the possible clinical usefulness of such compounds.

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Al-Sa'doni H. H. and Ferro A., Current Status and Future Possibilities of Nitric Oxide-Donor Drugs: Focus on S-Nitrosothiols, Mini-Reviews in Medicinal Chemistry 2005; 5 (3) . https://dx.doi.org/10.2174/1389557053175399