Prosequence-Mediated Disulfide Coupled Folding of the Peptide Hormones Guanylin and Uroguanylin

Title: Prosequence-Mediated Disulfide Coupled Folding of the Peptide Hormones Guanylin and Uroguanylin

Volume: 12 Issue: 2

Author(s): Thomas Lauber and Ute C. Marx

Affiliation:

Keywords: guanylin, uroguanylin, peptide hormone, proguanylin, prouroguanylin, prosequence, folding, disulfide bonds

Abstract: In contrast to their prohormones the mature peptide hormones guanylin and uroguanylin are not able to fold to their native disulfide connectivities upon oxidative folding. Structural properties of both peptide hormones and their precursor proteins as well as the role of their prosequences in proper disulfide coupled folding are reviewed. In addition, the structural behavior of a proguanylin mutant that closely resembles prouroguanylin has been investigated to gain further insight into structural properties of this homologous precursor protein.

Cite this article as:

Lauber Thomas and Marx C. Ute, Prosequence-Mediated Disulfide Coupled Folding of the Peptide Hormones Guanylin and Uroguanylin, Protein & Peptide Letters 2005; 12 (2) . https://dx.doi.org/10.2174/0929866053005836

DOI https://dx.doi.org/10.2174/0929866053005836	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305